Regular season
| Wk | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 1 | Sep 7, 2025 | vs | Lucas Oil Stadium | |||
| 2 | Sep 14, 2025 | vs | Lucas Oil Stadium | |||
| 3 | Sep 21, 2025 | @ | Nissan Stadium | |||
| 4 | Sep 28, 2025 | @ |
FOX
| SoFi Stadium | ||
| 5 | Oct 5, 2025 | vs |
FOX
| Lucas Oil Stadium | ||
| 6 | Oct 12, 2025 | vs |
FOX
| Lucas Oil Stadium | ||
| 7 | Oct 19, 2025 | @ | SoFi Stadium | |||
| 8 | Oct 26, 2025 | vs | Lucas Oil Stadium | |||
| 9 | Nov 2, 2025 | @ | Acrisure Stadium | |||
| 10 | Nov 9, 2025 | vs |
NFL+
| Olympiastadion | ||
| 11 | — |
BYE
| — | — | — | — |
| 12 | Nov 23, 2025 | @ | GEHA Field at Arrowhead Stadium | |||
| 13 | Nov 30, 2025 | vs | Lucas Oil Stadium | |||
| 14 | Dec 7, 2025 | @ | EverBank Stadium | |||
| 15 | Dec 14, 2025 | @ | Lumen Field | |||
| 16 | Dec 22, 2025 | vs |
ESPN
| Lucas Oil Stadium | ||
| 17 | Dec 28, 2025 | vs |
FOX
| Lucas Oil Stadium | ||
| 18 | Jan 4, 2026 | @ | — | NRG Stadium |
